TPDB

3D PDB MODEL

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TPDB ID TPDB92317

Peptide_Name

MAC1/21

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, ACP740 _ACP240, AntiCP 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GFGMALRLLRRVL-NH2

FASTA

>TPDB92317|Antibacterial;Anticancer;Antifungal;Toxicity|length=13
GFGMALRLLRRVL-NH2

Formula C68H120N22O14S1

Absent Amino Acids NDCEQHIKPSTWY

Common Amino Acids L

Mass 1501.90

PI 12.70

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index -1.25

Hydrophobicity 0.892

Aliphatic Index 150.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

3

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

0

I

4

L

0

K

1

M

1

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

13

Formula

C68H120N22O14S1

Mass

1501.90

PI

12.70

Net Charge

+3

Boman Index

-1.25

Hydrophobicity

0.892

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Macropins and their analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9±3 µM

Detail Source Activity Anticancer

Activity Measurement 9

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 17±2 µM

Detail Source Activity Anticancer

Activity Measurement 17

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 22±4 µM

Detail Source Activity Anticancer

Activity Measurement 22

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012