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Peptide record

TPDB92316

cHLHp53-R Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB92316
cHLHp53-R
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
GARELRRLERELRRLEGGGGGGGKLAALKFKLLWLKLAC-NH2
Physicochemical Analysis
C191H328N62O48S1
NDQHIMPSTYV
L
4293.15
11.36
10
4
16
+6
7.48
-0.262
110.26
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
128.11
1
Residue Composition
number
4
A
6
R
0
N
0
D
1
C
4
E
0
Q
8
G
0
H
0
I
10
L
4
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 1 E: 4 Q: 0 G: 8 H: 0 I: 0 L: 10 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
39
C191H328N62O48S1
4293.15
11.36
+6
7.48
-0.262
Amidation
L
Cationic
Cyclic
Free
N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Tetramethylrhodamine (TMR) labelled
Cytosol
Efficient cellular uptake in HeLa cells within a few minutes
In vitro
CCCCCSSCCCSSCGGGGGC
Additional Detail Fields 1 fields
CCCCCSSCCCSSCGGGGGC