TPDB

3D PDB MODEL

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TPDB ID TPDB92312

Peptide_Name

Longicalycinin A

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.

Modification

C-terminal: Cyclized N-terminal: Cyclized

Sequence

FYPFG

FASTA

>TPDB92312|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=5
FYPFG

Formula C34H39N5O7

Absent Amino Acids ARNDCEQHILKMSTWV

Common Amino Acids F

Mass 629.71

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -2.74

Hydrophobicity 0.460

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 236.62

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

2

F

1

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C34H39N5O7

Mass

629.71

PI

5.94

Net Charge

-0

Boman Index

-2.74

Hydrophobicity

0.460

C_terminal_Modification

Cyclized

Chirality

L

Linear_or_Cyclic

Cyclic

N_terminal_Modification

Cyclized

Nature

Anticancer

Origin

Dianthus superbus Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 13.52 µg/ml

Detail Source Activity Anticancer

Activity Measurement 13.52 µg/mL

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint CTC50

Activity Raw

CTC50 = 2.62 µM

Detail Source Activity Anticancer

Activity Measurement 2.62 µM

Target

Cancer Type Lung Cancer

Cell Line DLA cell line

Tissue Affected Thymus

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 3 Activity

Activity

Activity Endpoint CTC50

Activity Raw

CTC50 = 6.17 µM

Detail Source Activity Anticancer

Activity Measurement 6.17 µM

Target

Cancer Type Breast Cancer

Cell Line EAC cell Line

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 10.45 ± 0.0042 µg/ml

Detail Source Activity Anticancer

Activity Measurement 10.45

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.87 ± 0.0021 µg/ml

Detail Source Activity Anticancer

Activity Measurement 11.87

Target

Cancer Type Colorectal Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2020