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Peptide record

TPDB92310

Antibacterial Antifungal Toxicity modified_plain modified
17 amino acids
Basic Information
3D PDB MODEL
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TPDB92310
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 17-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
FXLXAXIXVXLXAXIXL
Physicochemical Analysis
C50H85N9O10
RNDCEQGHKMPSTWY
L
972.28
6.02
0
0
9
-0
-3.70
1.824
143.53
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
3
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C50H85N9O10
972.28
6.02
-0
-3.70
1.824
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Cell death
Toxicity
19 µg/mL
Cytotoxic
10% Cell death | 19 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment. | Antimicrob Agents Chemother | 2019
Evidence 2 Activity

Activity

90% Cell death
Toxicity
64 µg/mL
Cytotoxic
90% Cell death | 64 | µg/mL | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Designed Antimicrobial Peptides Against Trauma-Related Cutaneous Invasive Fungal Wound Infections. | J Fungi (Basel) | 2020
Evidence 3 Activity

Activity

50% Cell death
Toxicity
31 µg/mL
Cytotoxic
50% Cell death | 31 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Designed Antimicrobial Peptides for Topical Treatment of Antibiotic Resistant Acne Vulgaris. | Antibiotics (Basel) | 2020