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Peptide record

TPDB92307

DIM-LF11-318 Antibacterial Anticancer Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB92307
DIM-LF11-318
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
FWQRRIRRWRRFWQRRIRRWRR-NH2
Physicochemical Analysis
C156H242N64O25
ANDCEGHLKMPSTYV
R
3414.05
13.44
12
0
8
+12
0.60
-2.273
35.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
22000
644.40
2
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
22
C156H242N64O25
3414.05
13.44
+12
0.60
-2.273
Amidation
L
Linear
Free
Host Defence Peptide
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

LC50
LC50 = 3.8 ± 0.5 µM
Anticancer
3.8

Target

Skin Cancer
A-375
Skin

Assay & Model

PI uptake assay
8-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

LC50
LC50 = 9.3 ± 0.8 µM
Anticancer
9.3

Target

Skin Cancer
A-375
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015
Evidence 3 Activity

Activity

LC50
LC50 = 9.4 ± 0.5 µM
Anticancer
9.4

Target

Skin Cancer
SBcl2
Skin

Assay & Model

MTS assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2015