TPDB

3D PDB MODEL

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TPDB ID TPDB92298

Peptide_Name

HPRP-A1-TAT

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-FKKLKKLFSKLWNWKRKKRRQRRR-NH2

FASTA

>TPDB92298|Antibacterial;Anticancer;Toxicity|length=24
Ac-FKKLKKLFSKLWNWKRKKRRQRRR-NH2

Formula C154H260N54O28

Absent Amino Acids ADCEGHIMPTYV

Common Amino Acids K

Mass 3316.10

PI 13.11

Basic Residues 14

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +14

Boman Index 6.27

Hydrophobicity -2.117

Aliphatic Index 48.75

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 331.71

Polar Residues 3

number

0

A

6

R

1

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

3

L

8

K

0

M

2

F

0

P

1

S

0

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 8 M: 0 F: 2 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 0

Length

24

Formula

C154H260N54O28

Mass

3316.10

PI

13.11

Net Charge

+14

Boman Index

6.27

Hydrophobicity

-2.117

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Acetylation

Nature

Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 4.8 ± 0.08 µM

Detail Source Activity Anticancer

Activity Measurement 4.8

Target

Cancer Type Gastric cancer

Cell Line SGC-7901

Tissue Affected Stomach

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 5.8 ± 0.36 µM

Detail Source Activity Anticancer

Activity Measurement 5.8

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 3.9 ± 0.02 µM

Detail Source Activity Anticancer

Activity Measurement 3.9

Target

Cancer Type Skin Cancer

Cell Line B-16

Tissue Affected Skin

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 1.8 ± 0.02 µM

Detail Source Activity Anticancer

Activity Measurement 1.8

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2015