Back to search

Peptide record

TPDB92294

AP1-Z5b Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92294
AP1-Z5b
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Amidation
Sequence
FLFKLIKHAIKGLIKAFK-NH2
Physicochemical Analysis
C107H175N25O19
RNDCEQMPSTWYV
K
2115.72
11.12
6
0
11
+5
-0.42
0.767
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
3
I
3
L
5
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 5 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C107H175N25O19
2115.72
11.12
+5
-0.42
0.767
Amidation
L
Linear
Amidation
Antimicrobial
Mutant of APR-Z1
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 1.037 µM
Anticancer
1.037 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 2.607 µM
Anticancer
2.607 µM

Target

Skin Cancer
A-375
Skin

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

IC50
IC50 = 3.115 µM
Anticancer
3.115 µM

Target

Brain Tumor
U-87
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019