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Peptide record

TPDB92292

LL-37 Analogue 7 Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB92292
LL-37 Analogue 7
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and CAFPdb, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-FKRIVQRIRDFLR-NH2
Physicochemical Analysis
C80H135N27O17
ANCEGHMPSTWY
R
1747.12
12.41
5
1
6
+4
2.67
-0.485
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
1
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C80H135N27O17
1747.12
12.41
+4
2.67
-0.485
Amidation
L
Linear
Acetylation
Antimicrobial and Anticancer
Synthetic Analog of LL-37
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
IC50 = 12.5 µg/mL
Anticancer
12.5 µg/mL

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.