TPDB

3D PDB MODEL

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TPDB ID TPDB92276

Peptide_Name

Gageostatin A

Activity

Antibacterial Anticancer Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.

Modification

N-terminal: 3-beta-hydroxy-11-methyltridecanoic acid

Sequence

ELLVDLL

FASTA

>TPDB92276|Antibacterial;Anticancer;Antifungal;Antiviral;Toxicity|length=7
ELLVDLL

Formula C38H67N7O12

Absent Amino Acids ARNCQGHIKMFPSTWY

Common Amino Acids L

Mass 813.99

PI 3.01

Basic Residues 0

Acidic Residues 2

Hydrophobic Residues 5

Net Charge -2

Boman Index 1.08

Hydrophobicity 1.771

Aliphatic Index 264.29

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

1

E

0

Q

0

G

0

H

0

I

4

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

7

Formula

C38H67N7O12

Mass

813.99

PI

3.01

Net Charge

-2

Boman Index

1.08

Hydrophobicity

1.771

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

3-beta-hydroxy-11-methyltridecanoic acid

Nature

Antimicrobial

Origin

Bacillus subtilis

Evidence 1 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 14.9 µg/mL

Detail Source Activity Anticancer

Activity Measurement 14.9 µg/mL

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-231

Tissue Affected Breast

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 11.4 µg/mL

Detail Source Activity Anticancer

Activity Measurement 11.4 µg/mL

Target

Cancer Type Colon Cancer

Cell Line HCT-15

Tissue Affected Colon

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014

Evidence 3 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 10.8 µg/mL

Detail Source Activity Anticancer

Activity Measurement 10.8 µg/mL

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014

Evidence 4 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 11.2 µg/mL

Detail Source Activity Anticancer

Activity Measurement 11.2 µg/mL

Target

Cancer Type Lung Cancer

Cell Line NCI-H23

Tissue Affected Lung

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014

Evidence 5 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 11.8 µg/mL

Detail Source Activity Anticancer

Activity Measurement 11.8 µg/mL

Target

Cancer Type Stomach Cancer

Cell Line NUGC-3

Tissue Affected Stomach

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014

Evidence 6 Activity

Activity

Activity Endpoint GI50

Activity Raw

GI50 = 11.5 µg/mL

Detail Source Activity Anticancer

Activity Measurement 11.5 µg/mL

Target

Cancer Type Renal Cancer

Cell Line ACHN

Tissue Affected Kidney

Assay & Model

Assay Sulforhodamine B assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2014