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Peptide record

TPDB92258

IMT-P8 Antibacterial Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB92258
IMT-P8
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC via Ahx linker
Sequence
RRWRRWNRFNRRRCR
Physicochemical Analysis
C96H156N46O18S1
ADEQGHILKMPSTYV
R
2274.65
12.94
9
0
3
+9
3.06
-2.933
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
483.59
3
Residue Composition
number
0
A
9
R
2
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C96H156N46O18S1
2274.65
12.94
+9
3.06
-2.933
Free
L
Linear
Conjugated with FITC via Ahx linker
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, MDA-MB-231 , Rwpe-1 And PC3 Cells

Assay & Model

Skin of adult mice(Male BALB/c mice of 6–8 weeks and 22–25 g)
Skin of adult mice(Male BALB/c mice of 6–8 weeks and 22–25 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Green fluorescent protein (GFP) and proapoptotic peptide, KLA
Cytosol and Mitochondria
A significant intracellular FITC fluorescence was observed in HeLa, MDA-MB-231 and PC3 cells incubated with IMT-P8-KLA, while negligible fluorescence with FITC-KLA peptide. 60% HeLa cells were found to be GFP-positive when treated with IMT-P8-GFP compared to cells treated with TAT-GFP in which only 25% cells were GFP-positive.
Endocytosis
In vitro and in vivo
CCCCCCSGGGTGGGHHHHHHHHHHHTTCSBSSSCSSCCCBCC
Additional Detail Fields 1 fields
CCCCCCSGGGTGGGHHHHHHHHHHHTTCSBSSSCSSCCCBCC