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Peptide record

TPDB92255

pepR Antibacterial Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB92255
pepR
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 35-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
LKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRR
Physicochemical Analysis
C189H334N68O43S1
DCQHPY
R
4279.22
12.88
13
1
13
+12
8.22
-0.834
100.29
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
128.53
5
Residue Composition
number
1
A
8
R
3
N
0
D
0
C
1
E
0
Q
3
G
0
H
4
I
4
L
5
K
1
M
1
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 8 N: 3 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 4 L: 4 K: 5 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
35
C189H334N68O43S1
4279.22
12.88
+12
8.22
-0.834
Free
L
Cationic
Linear
Conjugation with rhodamine B
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HepG2, BHK and HEK cell lineages, astrocytes and PBMC

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (ssDNA oligonucleotide labelled with Alexa-488)
Cytosol
Endocytic pathway
In vitro
CCCCSSSCCCCCCHHHHHHHHHHHHHHHHHHTTCC
Additional Detail Fields 1 fields
CCCCSSSCCCCCCHHHHHHHHHHHHHHHHHHTTCC