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Peptide record

TPDB92251

(RXR)4XB-PNA Antibacterial Cell-penetrating Peptides modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB92251
(RXR)4XB-PNA
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Chemical: B = β-alanine, X = aminohexanoic acid, PNAs via a flexible ethylene glycol linker (8-amino-3,6-dioxaoctanoic acid)
Sequence
RXRRXRRXRRXRXB
Physicochemical Analysis
C48H98N32O9
ANDCEQGHILKMFPSTWYV
R
1267.52
13.25
8
0
0
+8
6.48
-2.571
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C48H98N32O9
1267.52
13.25
+8
6.48
-2.571
Free
B = β-alanine, X = aminohexanoic acid, PNAs via a flexible ethylene glycol linker (8-amino-3,6-dioxaoctanoic acid)
Modified
Linear
Free
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

S. Pneumoniae

Assay & Model

G. mellonella Larvae infected with S. pneumoniae
G. mellonella Larvae infected with S. pneumoniae

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
anti-gyrA PNA
(RXR)4XB-coupled antisense PNAs were more efficient than TAT-coupled antisense PNAs.
In vitro and in vivo
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. Pneumoniae

Assay & Model

G. mellonella Larvae infected with S. pneumoniae
G. mellonella Larvae infected with S. pneumoniae

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear Modified
Synthetic
anti-rpoB PNA
(RXR)4XB-coupled antisense PNAs were more efficient than TAT-coupled antisense PNAs.
In vitro and in vivo