TPDB

3D PDB MODEL

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TPDB ID TPDB92248

Peptide_Name

t-DPH1-6KW

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

WLWKKIKNVAKAAGKAAKGAL-NH2

FASTA

>TPDB92248|Antibacterial;Anticancer;Antifungal;Toxicity|length=21
WLWKKIKNVAKAAGKAAKGAL-NH2

Formula C107H178N30O23

Absent Amino Acids RDCEQHMFPSTY

Common Amino Acids AK

Mass 2252.78

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index 0.30

Hydrophobicity -0.114

Aliphatic Index 98.10

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 488.29

Polar Residues 1

number

6

A

0

R

1

N

0

D

0

C

0

E

0

Q

2

G

0

H

1

I

2

L

6

K

0

M

0

F

0

P

0

S

0

T

2

W

0

Y

1

V

Amino Acid Distribution

A: 6 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1

Length

21

Formula

C107H178N30O23

Mass

2252.78

PI

11.21

Net Charge

+6

Boman Index

0.30

Hydrophobicity

-0.114

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Analogue of t-DPH1

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 118.4 µM

Detail Source Activity Anticancer

Activity Measurement 118.4 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 180.8 µM

Detail Source Activity Anticancer

Activity Measurement 180.8 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 427.3 µM

Detail Source Activity Anticancer

Activity Measurement 427.3 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 1499 µM

Detail Source Activity Anticancer

Activity Measurement 1499 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021