TPDB

3D PDB MODEL

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TPDB ID TPDB92245

Peptide_Name

t-DPH1-K4

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GLWKKIKNVAAAAGKAALGAL-NH2

FASTA

>TPDB92245|Antibacterial;Anticancer;Antifungal;Toxicity|length=21
GLWKKIKNVAAAAGKAALGAL-NH2

Formula C95H163N27O23

Absent Amino Acids RDCEQHMFPSTY

Common Amino Acids A

Mass 2051.51

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +4

Boman Index -0.55

Hydrophobicity 0.548

Aliphatic Index 121.43

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 268.10

Polar Residues 1

number

7

A

0

R

1

N

0

D

0

C

0

E

0

Q

3

G

0

H

1

I

3

L

4

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 7 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

21

Formula

C95H163N27O23

Mass

2051.51

PI

11.00

Net Charge

+4

Boman Index

-0.55

Hydrophobicity

0.548

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Analogue of t-DPH1

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 18.99 µM

Detail Source Activity Anticancer

Activity Measurement 18.99 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 10.11 µM

Detail Source Activity Anticancer

Activity Measurement 10.11 µM

Target

Cancer Type Lung Cancer

Cell Line H-838

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 6.143 µM

Detail Source Activity Anticancer

Activity Measurement 6.143 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 32.18 µM

Detail Source Activity Anticancer

Activity Measurement 32.18 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2021