TPDB

3D PDB MODEL

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TPDB ID TPDB92242

Peptide_Name

LL-III/27

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

VNWKKVLGKVVKVVK-NH2

FASTA

>TPDB92242|Antibacterial;Anticancer;Antifungal;Toxicity|length=15
VNWKKVLGKVVKVVK-NH2

Formula C83H146N22O17

Absent Amino Acids ARDCEQHIMFPSTY

Common Amino Acids V

Mass 1724.21

PI 11.12

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +5

Boman Index 3.39

Hydrophobicity 0.313

Aliphatic Index 142.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 318.99

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

5

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

6

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 6

Length

15

Formula

C83H146N22O17

Mass

1724.21

PI

11.12

Net Charge

+5

Boman Index

3.39

Hydrophobicity

0.313

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Lasioglossin III and its analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 13±2 µM

Detail Source Activity Anticancer

Activity Measurement 13

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 18 µM

Detail Source Activity Anticancer

Activity Measurement 18 µM

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012