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Peptide record

TPDB92238

Antibacterial Anticancer Antifungal Antiparasitic Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB92238
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 CAFPdb
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
ZCRRLCYKQRCVTYCRGR
Physicochemical Analysis
C88H150N34O22S4
ANDEHIMFPSW
R
2164.61
10.10
6
0
4
+6
2.44
-0.867
37.78
Mammalian: Yeast: E.coli:
3230
149.22
8
Residue Composition
number
0
A
5
R
0
N
0
D
4
C
0
E
1
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 4 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C88H150N34O22S4
2164.61
10.10
+6
2.44
-0.867
Evidence Records 1 records
Evidence 1 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28741926] It has 0% hemolysis at 6 µM , 3% hemolysis at 10 µM , 10% hemolysis at 5 µM , 41.2-53.2% hemolysis at 64 µM , 50% hemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.28741926] CC50 = 67.0 ± 5.0 µM against CRL-1739, CC50 = 3.7 ± 0.2 µM against MM96L, CC50 = 49.9 ±16.6µM against HFF-1, CC50 =54.1±5.0 µM against HeLa, CC50 = 3.8 ± 0.3 µM against K-562.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2000 Oct 27 275(43):33464-33470.##ACS Chem Biol. 2017 Sep 15 12(9):2324-2334. doi: 10.1021/acschembio.7b00459.