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Peptide record

TPDB92237

L6 ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB92237
L6
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP DRAMP CAFPdb AHTPDB AHTpin dbAMP 3.0 CPPsite3.0 PD_Hemolysis
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, dbAMP, DRAMP, and other sources, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
RRWQWR
Physicochemical Analysis
C45H66N18O8
ANDCEGHILKMFPSTYV
R
987.13
12.70
3
0
2
+3
-0.69
-3.133
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1114.34
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
6
C45H66N18O8
987.13
12.70
+3
-0.69
-3.133
Free
L
Cationic
Linear
Conjugated with FITC
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
FITC dye
L6-FITC were internalized at low concentrations (< 1μM)
In vitro
CCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Protein derived
FITC dye
In vitro
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
FITC dye and Quantum dots(FN-525-C-25MG)
Lysosomes, Early Endosomes, And Membranes
Efficiently deliver QDs into cells
Endocytosis
In vitro
CCCSCCSSSSSSCCCCCCC
Additional Detail Fields 1 fields
CCCCCC CCCSCCSSSSSSCCCCCCC