Back to search

Peptide record

TPDB92233

Tm3+-DOTA-CAT Antibacterial Anticancer Antiviral Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92233
Tm3+-DOTA-CAT
Antibacterial Anticancer Antiviral Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
dbAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AI4AVP dbAMP 3.0 DRAVP 2.0 CellPPD CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from dbAMP, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugated with Tm³⁺-DOTA via CAT recognition site
Sequence
GRKKRRQRRR
Physicochemical Analysis
C55H109N31O12
ANDCEHILMFPSTWYV
R
1396.67
13.10
8
0
0
+8
7.43
-3.870
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C55H109N31O12
1396.67
13.10
+8
7.43
-3.870
Free
L
Cationic
Linear
Conjugated with Tm³⁺-DOTA via CAT recognition site
NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SN56 cells

Assay & Model

APP/PS1-dE9 mice
APP/PS1-dE9 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
MRI probe [DOTA-caged metal ion (Tm³?)]
Cat-D expression increases uptake of Tm3+-DOTA-CAT in neuronal SN56 cells
In vitro and in vivo
CCCCCCTTCC
Additional Detail Fields 1 fields
CCCCCCTTCC