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Peptide record

TPDB92222

TAT Antibacterial Anticancer Antiviral Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92222
TAT
Antibacterial Anticancer Antiviral Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
dbAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AI4AVP dbAMP 3.0 DRAVP 2.0 CellPPD CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from dbAMP, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation Chemical: Micelle N-terminal: Gamma-CHOlesterol Glutamate (Glu-CHOl) Via His Tag
Sequence
GRKKRRQRRR-NH2
Physicochemical Analysis
C55H109N31O12
ANDCEHILMFPSTWYV
R
1396.67
13.10
8
0
0
+8
7.43
-3.870
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C55H109N31O12
1396.67
13.10
+8
7.43
-3.870
Amidation
Micelle
L
Cationic
Linear
Gamma-CHOlesterol Glutamate (Glu-CHOl) Via His Tag
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hepg2 Cells

Assay & Model

HCC xenograft model of nude mice 6–8 weeks
HCC xenograft model of nude mice 6–8 weeks

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorescent dye Rhod and siULK1
Fluorescence intensity of FITC-siULK1 and Rhod when delivered in micelles was 2.3- and 9.7-fold higher than when delivered as free siULK1 and free dye.
In vitro and in vivo
CCTTSCCSCC
Additional Detail Fields 1 fields
CCTTSCCSCC