TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB92221

Peptide_Name

Dermaseptin-PS4

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

ALWKTLLKHVGKAAGKAALNAVTDMVNQ-NH2

FASTA

>TPDB92221|Antibacterial;Anticancer;Antifungal;Toxicity|length=28
ALWKTLLKHVGKAAGKAALNAVTDMVNQ-NH2

Formula C132H222N38O36S1

Absent Amino Acids RCEIFPSY

Common Amino Acids A

Mass 2949.51

PI 10.55

Basic Residues 5

Acidic Residues 1

Hydrophobic Residues 15

Net Charge +3

Boman Index 2.74

Hydrophobicity 0.164

Aliphatic Index 108.21

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 186.47

Polar Residues 5

number

6

A

0

R

2

N

1

D

0

C

0

E

1

Q

2

G

1

H

0

I

4

L

4

K

1

M

0

F

0

P

0

S

2

T

1

W

0

Y

3

V

Amino Acid Distribution

A: 6 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 3

Length

28

Formula

C132H222N38O36S1

Mass

2949.51

PI

10.55

Net Charge

+3

Boman Index

2.74

Hydrophobicity

0.164

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Phyllomedusa sauvagii

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 57.66 nM

Detail Source Activity Anticancer

Activity Measurement 57.66 nM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.11 µM

Detail Source Activity Anticancer

Activity Measurement 0.11 µM

Target

Cancer Type Breast Cancer

Cell Line MDA-MB-435S

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.19 µM

Detail Source Activity Anticancer

Activity Measurement 0.19 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.44 µM

Detail Source Activity Anticancer

Activity Measurement 0.44 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 0.67 µM

Detail Source Activity Anticancer

Activity Measurement 0.67 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019