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Peptide record

TPDB92212

mTP Antibacterial Cell-penetrating Peptides Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92212
mTP
Antibacterial Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP PD_Hemolysis
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Chemical: 5-carboxyfluorescein labelled calcium silicate - porous silicon nanoparticle modified with rabies virus glycoprotein (RVG) via PEG linker [Ca-pSiNP-DPNC] N-terminal: Myrsitoylation
Sequence
GWTLNSAGYLLGKINLKALAALAKKIL
Physicochemical Analysis
C134H226N34O33
RDCEQHMFPV
L
2841.48
10.64
4
0
16
+4
-3.08
0.633
148.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
246.00
5
Residue Composition
number
5
A
0
R
2
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
7
L
4
K
0
M
0
F
0
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 7 K: 4 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
27
C134H226N34O33
2841.48
10.64
+4
-3.08
0.633
Free
5-carboxyfluorescein labelled calcium silicate - porous silicon nanoparticle modified with rabies virus glycoprotein (RVG) via PEG linker [Ca-pSiNP-DPNC]
L
Linear
Myrsitoylation
N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neuro-2A Cells

Assay & Model

Mice brain injury model
Mice brain injury model

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
siRNA
Cytoplasm
Greater efficacy of targeting by the dual peptide Ca-pSiNP-siRNA-DPNC(2-fold greater intensity of fluorescence) relative to the untargeted nanoparticles Ca-pSiNP-siRNA-PEG
In vitro and in vivo
CCSTTSCCSCCC
Additional Detail Fields 1 fields
CCSTTSCCSCCC