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Peptide record

TPDB92202

APIM ATX-101 Antibacterial Anticancer Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB92202
APIM ATX-101
Antibacterial Anticancer Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 CPPsite3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
N-terminal: Acetylation
Sequence
Ac-MDRWLVKWKKKRKIRRRRRRRRRRR
Physicochemical Analysis
C156H283N71O28S1
ANCEQGHFPSTY
R
3633.48
13.14
18
1
6
+17
11.98
-2.756
42.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
302.74
0
Residue Composition
number
0
A
13
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
5
K
1
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 13 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 5 M: 1 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
25
C156H283N71O28S1
3633.48
13.14
+17
11.98
-2.756
Free
L
Linear
Linear
Acetylation
Antitumor and Cell Penetrating
Synthetic
N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 13 records
Evidence 1 Activity

Activity

IC50
IC50 = 4.3 ± 0.3 µM
Anticancer
4.3

Target

Brain Tumor
U87-MG
Brain

Assay & Model

CCK-8 assay
96-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 4.9 ± 0.3 µM
Anticancer
4.9

Target

Brain Tumor
U-251
Brain

Assay & Model

CCK-8 assay
96-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 3 Activity

Activity

IC50
IC50 = 6.4 ± 0.4 µM
Anticancer
6.4

Target

Brain Tumor
A-172
Brain

Assay & Model

CCK-8 assay
96-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 4 Activity

Activity

IC50
IC50 = 7.1 ± 0.2 µM
Anticancer
7.1

Target

Brain Tumor
T98G
Brain

Assay & Model

CCK-8 assay
96-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 5 Activity

Activity

IC50
IC50 = 5.0 ± 0.2 µM
Anticancer
5.0

Target

Brain Tumor
U-373
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 6 Activity

Activity

IC50
IC50 = 6.8 ± 0.2 µM
Anticancer
6.8

Target

Brain Tumor
U-118
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 7 Activity

Activity

IC50
IC50 = 8.4 ± 0.1 µM
Anticancer
8.4

Target

Brain Tumor
D54
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 8 Activity

Activity

IC50
IC50 = 4.8 ± 0.2 µM
Anticancer
4.8

Target

Brain Tumor
SW-1783
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 9 Activity

Activity

IC50
IC50 = 4.7 ± 0.2 µM
Anticancer
4.7

Target

Brain Tumor
LN229
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 10 Activity

Activity

IC50
IC50 = 7.5 ± 0.3 µM
Anticancer
7.5

Target

Brain Tumor
U-138
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 11 Activity

Activity

IC50
IC50 = 4.8 ± 0.1 µM
Anticancer
4.8

Target

Brain Tumor
SF-268
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 12 Activity

Activity

IC50
IC50 = 12.0 ± 0.6 µM
Anticancer
12.0

Target

Brain Tumor
SNB-19
Brain

Assay & Model

CCK-8 assay
72-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2022
Evidence 13 Activity

Activity

Cell-penetrating Peptides

Target

4T1, B16-F0, A549, MDA-MB-23, Hepg2 And Panc-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
In vitro
CCCCHHHHHHHTTGGGGGGCCCCCC
Additional Detail Fields 1 fields
CCCCHHHHHHHTTGGGGGGCCCCCC