TPDB

3D PDB MODEL

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TPDB ID TPDB92201

Peptide_Name

Dermaseptin-PT9

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GLWSKIKDAAKTAGKAALGFVNEMV-NH2

FASTA

>TPDB92201|Antibacterial;Anticancer;Antifungal;Toxicity|length=25
GLWSKIKDAAKTAGKAALGFVNEMV-NH2

Formula C118H193N31O33S1

Absent Amino Acids RCQHPY

Common Amino Acids A

Mass 2606.08

PI 10.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 13

Net Charge +2

Boman Index 2.58

Hydrophobicity 0.180

Aliphatic Index 90.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 211.05

Polar Residues 3

number

5

A

0

R

1

N

1

D

0

C

1

E

0

Q

3

G

0

H

1

I

2

L

4

K

1

M

1

F

0

P

1

S

1

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 5 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 4 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 2

Length

25

Formula

C118H193N31O33S1

Mass

2606.08

PI

10.16

Net Charge

+2

Boman Index

2.58

Hydrophobicity

0.180

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Phyllomedusa tarsius

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 7.44 µM

Detail Source Activity Anticancer

Activity Measurement 7.44 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 49.51 µM

Detail Source Activity Anticancer

Activity Measurement 49.51 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 25.51 µM

Detail Source Activity Anticancer

Activity Measurement 25.51 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 21.78 µM

Detail Source Activity Anticancer

Activity Measurement 21.78 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 28.95 µM

Detail Source Activity Anticancer

Activity Measurement 28.95 µM

Target

Cancer Type Pancreatic Cancer

Cell Line PANC-1

Tissue Affected Pancreas

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019