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Peptide record

TPDB92200

Ziconotide SNX-111 Antibacterial Antifungal Blood-Brain Barrier Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB92200
Ziconotide SNX-111
Antibacterial Antifungal Blood-Brain Barrier Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP B3Pred BBPpredict pep-lab ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Blood-Brain Barrier, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Chemical: Cys1-Cys16 Chemical: Cys15-Cys25 Chemical: Cys8-Cys20
Sequence
CKGKGAKCSRLMYDCCTGSCRSGKC
Physicochemical Analysis
C102H177N35O33S7
NEQHIFPWV
C
2646.16
8.89
6
1
4
+5
4.04
-0.464
19.60
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
70.48
11
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
0
E
0
Q
4
G
0
H
0
I
1
L
4
K
1
M
0
F
0
P
3
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 1 K: 4 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C102H177N35O33S7
2646.16
8.89
+5
4.04
-0.464
Cys1-Cys16 Cys8-Cys20 Cys15-Cys25
Linear
Similarity
Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys
C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N3)CO)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CO)CCCNC(=N)N)CC(C)C)CCSC)CC4=CC=C(C=C4)O)CC(=O)O)C(=O)N)CCCCN)CO)CCCNC(=N)N)CCCCN
Evidence Records 4 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0042 mL/(g x min)

Assay & Model

Origin/Source
Unidirectional flux rate constant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
Permeability
Direct iodination
Evidence 2 Activity

Activity

Blood-Brain Barrier
0.0018 ml/g

Assay & Model

Origin/Source
Initial distribution vaolume

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
in situ brain perfusion
Permeability
Direct iodination
Evidence 3 Activity

Activity

Blood-Brain Barrier
1.31%

Assay & Model

Capillary depletion
Origin/Source
Rpellet

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Evidence 4 Activity

Activity

Blood-Brain Barrier
5.58%

Assay & Model

Capillary depletion
Origin/Source
Rsupernatant

Source & Reference

NA
B3Pdb

Other

Chemically synthesized
Direct iodination
Additional Detail Fields 1 fields
in situ brain perfusion