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Peptide record

TPDB92199

MVIIA (ziconotide) Antibacterial Antifungal Blood-Brain Barrier Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB92199
MVIIA (ziconotide)
Antibacterial Antifungal Blood-Brain Barrier Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP B3Pred BBPpredict pep-lab ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Blood-Brain Barrier, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
C-terminal: TAT-transducing domain was fused at C-terminal
Sequence
CKGKGAKCSRLMYDCCTGSCRSGKC
Physicochemical Analysis
C102H177N35O33S7
NEQHIFPWV
C
2646.16
8.89
6
1
4
+5
4.04
-0.464
19.60
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
70.48
11
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
0
E
0
Q
4
G
0
H
0
I
1
L
4
K
1
M
0
F
0
P
3
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 1 K: 4 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C102H177N35O33S7
2646.16
8.89
+5
4.04
-0.464
TAT-transducing domain was fused at C-terminal
Linear
Similarity
Cationic
CysLysGlyLysGlyAlaLysCysSerArgLeuMetTyrAspCysCysThrGlySerCysArgSerGlyLysCys
N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Blood-Brain Barrier
0.0436 micromolar

Target

HEK293 cells

Assay & Model

Acetic Acid-Induced WRITHING test
Inhibitory activity toward N-type calcium channels.
Origin/Source
Tremor Symptom Test
It induces tremor symptoms
MIC

Source & Reference

NA
B3Pdb

Other

Intranasal and Intervenous
It showed that C-terminal fusion with TAT peptide render its BBB penetration capacity, without signi
Receptor-mediated transcytosis
Comined with TAT-protein
Additional Detail Fields 1 fields
Intranasal and Intervenous