TPDB

3D PDB MODEL

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TPDB ID TPDB92198

Peptide_Name

23-DPT9 K8

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GLWSKIKKAAKTAGKAALGFVNKMV-NH2

FASTA

>TPDB92198|Antibacterial;Anticancer;Antifungal;Toxicity|length=25
GLWSKIKKAAKTAGKAALGFVNKMV-NH2

Formula C121H205N33O29S1

Absent Amino Acids RDCEQHPY

Common Amino Acids K

Mass 2618.22

PI 11.21

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +6

Boman Index 1.31

Hydrophobicity 0.148

Aliphatic Index 90.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 210.07

Polar Residues 3

number

5

A

0

R

1

N

0

D

0

C

0

E

0

Q

3

G

0

H

1

I

2

L

6

K

1

M

1

F

0

P

1

S

1

T

1

W

0

Y

2

V

Amino Acid Distribution

A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 6 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 2

Length

25

Formula

C121H205N33O29S1

Mass

2618.22

PI

11.21

Net Charge

+6

Boman Index

1.31

Hydrophobicity

0.148

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 8.64 µM

Detail Source Activity Anticancer

Activity Measurement 8.64 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 18.51 µM

Detail Source Activity Anticancer

Activity Measurement 18.51 µM

Target

Cancer Type Brain Tumor

Cell Line U251-MG

Tissue Affected Brain

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.88 µM

Detail Source Activity Anticancer

Activity Measurement 9.88 µM

Target

Cancer Type Lung Cancer

Cell Line H-157

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 9.97 µM

Detail Source Activity Anticancer

Activity Measurement 9.97 µM

Target

Cancer Type Prostate Cancer

Cell Line PC-3

Tissue Affected Prostate

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.17 µM

Detail Source Activity Anticancer

Activity Measurement 11.17 µM

Target

Cancer Type Pancreatic Cancer

Cell Line PANC-1

Tissue Affected Pancreas

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0

Source CancerPPD2

Year 2019