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Peptide record

TPDB92192

Phylloseptin-PBa1 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB92192
Phylloseptin-PBa1
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
FLSLIPHIASGIASLVKNF-NH2
Physicochemical Analysis
C97H155N23O24
RDCEQMTWY
ILS
2027.44
10.10
2
0
11
+1
-1.92
1.226
148.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
3
I
3
L
1
K
0
M
2
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 1 M: 0 F: 2 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C97H155N23O24
2027.44
10.10
+1
-1.92
1.226
Amidation
L
Linear
Free
Antimicrobial
Phyllomedusa burmeisteri
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 0.50 µM
Anticancer
0.50 µM

Target

Breast Cancer
MDA-MB-435S
Breast

Assay & Model

MTT assay
72-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Cell viability
Cell viability ~ 40% at 10-5 M
Anticancer
~40 % at 10-5 M

Target

Brain Tumor
U251-MG
Brain

Assay & Model

MTT assay
72-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 3 Activity

Activity

Cell viability
Cell viability ~ 50% at 10-5 M
Anticancer
~50 % at 10-5 M

Target

Prostate Cancer
DU-145
Prostate

Assay & Model

MTT assay
72-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 4 Activity

Activity

Cell viability
Cell viability < 50% at 10-5 M
Anticancer
<50 % at 10-5 M

Target

Lung Cancer
H-460
Lung

Assay & Model

MTT assay
72-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 5 Activity

Activity

Cell viability
Cell viability ~ 65% at 10-5 M
Anticancer
~65 % at 10-5 M

Target

Lung Cancer
H-838
Lung

Assay & Model

MTT assay
72-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019