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Peptide record

TPDB92190

L2 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB92190
L2
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
DILIIVGGGSGKERKKRRR-NH2
Physicochemical Analysis
C91H168N34O25
ANCQHMFPTWY
RG
2138.55
11.98
7
2
5
+5
8.21
-0.926
97.37
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
1
D
0
C
1
E
0
Q
4
G
0
H
3
I
1
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 3 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
19
C91H168N34O25
2138.55
11.98
+5
8.21
-0.926
Amidation
L
Cationic
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O.C(O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7 And Infected With S. Agalactiae H93

Assay & Model

Female ICR mice
Female ICR mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
FITC dye
Vacuole
Cell internalization ratio reached 97.4% higher than L10
Macropinocytosis
In vitro and in vivo
CCCCCCSSSCCSSSSCCCSCC
Additional Detail Fields 1 fields
CCCCCCSSSCCSSSSCCCSCC