TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB92187

Peptide_Name

Figainin 1

Activity

Antibacterial Anticancer Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CancerPPD 2.0 dbACP dbAMP 3.0 Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

FIGTLIPLALGALTKLFK-NH2

FASTA

>TPDB92187|Antibacterial;Anticancer;Antiparasitic;Hemolysis;Toxicity|length=18
FIGTLIPLALGALTKLFK-NH2

Formula C95H158N20O21

Absent Amino Acids RNDCEQHMSWYV

Common Amino Acids L

Mass 1916.42

PI 10.60

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +2

Boman Index -3.29

Hydrophobicity 1.422

Aliphatic Index 162.78

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

2

I

5

L

2

K

0

M

2

F

1

P

0

S

2

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 2 M: 0 F: 2 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 0

Length

18

Formula

C95H158N20O21

Mass

1916.42

PI

10.60

Net Charge

+2

Boman Index

-3.29

Hydrophobicity

1.422

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer

Origin

Boana raniceps

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 13.7 µM

Detail Source Activity Anticancer

Activity Measurement 13.7 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2020

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 11.1 µM

Detail Source Activity Anticancer

Activity Measurement 11.1 µM

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2020

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 10.5 µM

Detail Source Activity Anticancer

Activity Measurement 10.5 µM

Target

Cancer Type Skin Cancer

Cell Line B16-F10

Tissue Affected Skin

Assay & Model

Assay MTT assay

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2020