TPDB

3D PDB MODEL

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TPDB ID TPDB92179

Peptide_Name

MAC2

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

GTGLPMSERRKIMLMMR-NH2

FASTA

>TPDB92179|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=17
GTGLPMSERRKIMLMMR-NH2

Formula C83H151N27O22S4

Absent Amino Acids ANDCQHFWYV

Common Amino Acids M

Mass 2007.52

PI 12.12

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 7

Net Charge +3

Boman Index 3.83

Hydrophobicity -0.300

Aliphatic Index 68.82

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

3

R

0

N

0

D

0

C

1

E

0

Q

2

G

0

H

1

I

2

L

1

K

4

M

0

F

1

P

1

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 1 M: 4 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

17

Formula

C83H151N27O22S4

Mass

2007.52

PI

12.12

Net Charge

+3

Boman Index

3.83

Hydrophobicity

-0.300

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Antifungal

Origin

Macropins and their analogs

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 > 100 µM

Detail Source Activity Anticancer

Activity Measurement 100 µM

Target

Cancer Type Colon Cancer

Cell Line SW

Tissue Affected Colon

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 32 µM

Detail Source Activity Anticancer

Activity Measurement 32 µM

Target

Cancer Type Leukemia Cancer

Cell Line CCRF-CEM

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2012