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Peptide record

TPDB92173

TAT–SISLL Antibacterial Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB92173
TAT–SISLL
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Brca1 (782–786)
Sequence
YGRKKRRQRRRSISLL
Physicochemical Analysis
C88H161N37O21
ANDCEHMFPTWV
R
2073.48
12.71
8
0
4
+8
5.32
-1.844
73.12
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
71.86
4
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
2
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 2 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C88H161N37O21
2073.48
12.71
+8
5.32
-1.844
Brca1 (782–786)
L
Cationic and hydrophilic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Gram-Positive (Staphylococcus Aureus And Bacillus Subtilis ) And Gram-Negative (Salmonella Typhimurium And Escherichia Coli )

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and hydrophilic
Fusogenic
SISLL–TAT exhibited better antibacterial activities than TAT-SISLL.
In vitro
CCSCGGGSCSCCCCCC
Additional Detail Fields 1 fields
CCSCGGGSCSCCCCCC