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Peptide record

TPDB92150

neuroVAL Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB92150
neuroVAL
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CAFPdb dbAMP CPPsite3.0 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
IFWLFRGKADVAL-NH2
Physicochemical Analysis
C76H114N18O16
NCEQHMPSTY
ALF
1535.85
10.09
2
1
9
+1
-2.77
0.946
127.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
358.11
0
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
1
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C76H114N18O16
1535.85
10.09
+1
-2.77
0.946
Amidation
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hct116 And Hek293 Cells.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Alexa Fluor 488 dye
Internalized into the cells with a FC50 of 0.18 µM for HCT116 and 0.09 µM for HEK293
In vitro
CGGGGGSTTTC
Additional Detail Fields 1 fields
CGGGGGSTTTC