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Peptide record

TPDB92135

CPP (Dex-3) Antibacterial Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92135
CPP (Dex-3)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Chemical: Alexa 488 labelling N-terminal: Amidation
Sequence
AAVLLPVLLAAP
Physicochemical Analysis
C56H98N12O13
RNDCEQGHIKMFSTWY
AL
1147.47
6.02
0
0
10
-0
-1.88
2.300
211.67
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
12
C56H98N12O13
1147.47
6.02
-0
-1.88
2.300
Free
Alexa 488 labelling
L
Linear
Amidation
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ARPE-19 Cells

Assay & Model

Pigmented 2.5–3.0 kg female Dutch belted rabbits
Pigmented 2.5–3.0 kg female Dutch belted rabbits

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Dexamethasone via cleavable peptide-based linker (PCL)
Conjugates were internalized within the ARPE-19 cells without association at the cell surface
In vitro and in vivo
CCCCCSSTTTCC
Additional Detail Fields 1 fields
CCCCCSSTTTCC