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Peptide record

TPDB92128

Protonectin-F Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB92128
Protonectin-F
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CancerPPD 2.0 CAFPdb dbAMP CPPsite3.0 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
IFGTILGFLKGL-NH2
Physicochemical Analysis
C64H103N13O14
ARNDCEQHMPSWYV
GL
1278.60
10.10
1
0
7
+1
-3.40
1.683
162.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
3
L
1
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 3 K: 1 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C64H103N13O14
1278.60
10.10
+1
-3.40
1.683
Amidation
L
Amphipathic
Linear
Linear
Free
Antimicrobial
Protonoectin
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

CC50
CC50 = 16.0 ± 1.2 µM
Anticancer
16.0

Target

Skin Cancer
MM96L
Skin

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

CC50
CC50 = 9.8 ± 1.2 µM
Anticancer
9.8

Target

Colon Cancer
HCT-116
Colon

Assay & Model

Resazurin dye assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2021
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Hct116 And Hek293 Cells.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Alexa Fluor 488 dye
Internalized into both the cells with FC50 of 0.16 and 0.17 µM for HCT116 and HEK293
In vitro
CCHHHHHHHTCC
Additional Detail Fields 1 fields
CCHHHHHHHTCC