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Peptide record

TPDB92123

AMP-2 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92123
AMP-2
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: 5(6)-CF at N terminus
Sequence
EKKRLLKWWR-NH2
Physicochemical Analysis
C69H111N21O13
ANDCQGHIMFPSTYV
K
1442.77
11.56
5
1
4
+4
1.79
-1.840
78.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
11000
762.42
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C69H111N21O13
1442.77
11.56
+4
1.79
-1.840
Amidation
5(6)-CF at N terminus
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mrsa Membranes And Mrsa‐Infected Hek‐293 Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Liposome containing oleic acid (OA) and vancomycin
AMP2-Lipo-1 and AMP3-Lipo-2 had lower CFU counts compared to VCM.
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC