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Peptide record

TPDB92113

AMP-3 Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB92113
AMP-3
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: 5(6)-CF at N terminus
Sequence
KWWKLLRKKR-NH2
Physicochemical Analysis
C70H116N22O11
ANDCEQGHIMFPSTYV
K
1441.83
12.44
6
0
4
+6
0.76
-1.880
78.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
762.92
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C70H116N22O11
1441.83
12.44
+6
0.76
-1.880
Amidation
5(6)-CF at N terminus
L
Cationic
Linear
Free
N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mrsa Membranes And Mrsa‐Infected Hek‐293 Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Liposome containing oleic acid (OA) and vancomycin
AMP2-Lipo-1 and AMP3-Lipo-2 had lower CFU counts compared to VCM.
In vitro
CCCCCBTTBC
Additional Detail Fields 1 fields
CCCCCBTTBC