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Peptide record

TPDB92107

Cecropin B (antimicrobial peptide) Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB92107
Cecropin B (antimicrobial peptide)
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AI4AVP CPPsite3.0 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
N-terminal: Conjugated with 6-Carboxyfluorescein (6-Fam)
Sequence
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL
Physicochemical Analysis
C176H301N51O42S1
DCQHSTY
K
3835.70
11.23
9
2
17
+7
7.71
-0.071
106.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
143.39
2
Residue Composition
number
5
A
2
R
2
N
0
D
0
C
2
E
0
Q
4
G
0
H
4
I
2
L
7
K
1
M
1
F
1
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 7 M: 1 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C176H301N51O42S1
3835.70
11.23
+7
7.71
-0.071
Free
L
Linear
Conjugated with 6-Carboxyfluorescein (6-Fam)
N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C. Albicans Strain Sc5314 And C. Glabrata Strain Atcc2011

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
5-carboxyfluorescein (FAM) conjugated
Cytosol and Vacuole
Cecropin B (+9) exhibited a high level of translocation
Energy-dependent endocytosis or direct translocation/pore formation
In vitro
CTTTSCCCCHHHHHTGGGGTC
Additional Detail Fields 1 fields
CTTTSCCCCHHHHHTGGGGTC