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Peptide record

TPDB92105

Cecropin B Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity standard

35 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB92105

Peptide_Name

Cecropin B

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AI4AVP CPPsite3.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2

FASTA

>TPDB92105|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Cell-penetrating Peptides;Toxicity|length=35
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2

Formula C176H301N51O42S1

Absent Amino Acids DCQHSTY

Common Amino Acids K

Mass 3835.70

PI 11.23

Basic Residues 9

Acidic Residues 2

Hydrophobic Residues 17

Net Charge +7

Boman Index 7.71

Hydrophobicity -0.071

Aliphatic Index 106.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 143.39

Polar Residues 2

number

Amino Acid Distribution

A: 5 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 7 M: 1 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 3

Length

Formula

C176H301N51O42S1

Mass

3835.70

11.23

Net Charge

Boman Index

7.71

Hydrophobicity

-0.071

C_terminal_Modification

Amidation

Chirality

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Hyalophora Cecropia(silkmoth)

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=15.5 µM

Detail Source Activity Anticancer

Activity Measurement 15.5 µM

Target

Cancer Type Leukemia Cancer

Cell Line K-562

Tissue Affected Blood

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=24.8 µM

Detail Source Activity Anticancer

Activity Measurement 24.8 µM

Target

Cancer Type Breast Cancer

Cell Line BTS-30

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=25.5 µM

Detail Source Activity Anticancer

Activity Measurement 25.5 µM

Target

Cancer Type Colon Cancer

Cell Line HRT-18

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=>100 µM

Detail Source Activity Anticancer

Activity Measurement >100 µM

Target

Cancer Type Colon Cancer

Cell Line DLD-1

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 5 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=4.4 µM

Detail Source Activity Anticancer

Activity Measurement 4.4 µM

Target

Cancer Type Leukemia Cancer

Cell Line WEHI-3B

Tissue Affected Blood

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 6 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=30.6 µM

Detail Source Activity Anticancer

Activity Measurement 30.6 µM

Target

Cancer Type Ovarian Cancer

Cell Line A-2780

Tissue Affected Ovary

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 7 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=33.5 µM

Detail Source Activity Anticancer

Activity Measurement 33.5 µM

Target

Cancer Type Colon Cancer

Cell Line HCLO

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 8 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=32 µM

Detail Source Activity Anticancer

Activity Measurement 32 µM

Target

Cancer Type Ovarian Cancer

Cell Line CHO-KI

Tissue Affected Ovary

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 9 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=37 µM

Detail Source Activity Anticancer

Activity Measurement 37 µM

Target

Cancer Type Colon Cancer

Cell Line MAC15A

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 10 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=42.5 µM

Detail Source Activity Anticancer

Activity Measurement 42.5 µM

Target

Cancer Type Breast Cancer

Cell Line MCF-7

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 11 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=>100 µM

Detail Source Activity Anticancer

Activity Measurement >100 µM

Target

Cancer Type Colon Cancer

Cell Line HT-29

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 12 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=34.5

Detail Source Activity Anticancer

Activity Measurement 34.5

Target

Cancer Type Ovarian Cancer

Cell Line A-2780R

Tissue Affected Ovary

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994

Evidence 13 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=24.5

Detail Source Activity Anticancer

Activity Measurement 24.5

Target

Cancer Type Breast Cancer

Cell Line MCF-7R

Tissue Affected Breast

Assay & Model

Assay MTT assay

Testing Time 96-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 1994