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Peptide record

TPDB92099

Dermaseptin-PS1 Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB92099
Dermaseptin-PS1
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
ALWKTMLKKLGTVALHAGKAALGAVADTISQ-NH2
Physicochemical Analysis
C143H243N39O39S1
RNCEFPY
A
3164.80
10.55
5
1
17
+3
1.07
0.503
116.77
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
173.79
5
Residue Composition
number
7
A
0
R
0
N
1
D
0
C
0
E
1
Q
3
G
1
H
1
I
5
L
4
K
1
M
0
F
0
P
1
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 1 I: 1 L: 5 K: 4 M: 1 F: 0 P: 0 S: 1 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
31
C143H243N39O39S1
3164.80
10.55
+3
1.07
0.503
Amidation
L
Linear
Free
Antimicrobial
Phyllomedusa sauvagei
Evidence Records 2 records
Evidence 1 Activity

Activity

5.419 µmol/L
Anticancer

Target

Brain Tumor
U251-MG
Brain

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

20% LDH release at 10⁻⁴ M
Anticancer

Target

Brain Tumor
U251-MG
Brain

Assay & Model

LDH leakage assay
24-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019