TPDB

3D PDB MODEL

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TPDB ID TPDB92095

Peptide_Name

[P5K,D9K]Hymenochirin-1B

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation

Sequence

IKLSKETKKNLKKVLKGAIKGAIAVAKMV-NH2

FASTA

>TPDB92095|Antibacterial;Anticancer;Antifungal;Toxicity|length=29
IKLSKETKKNLKKVLKGAIKGAIAVAKMV-NH2

Formula C142H263N39O35S1

Absent Amino Acids RDCQHFPWY

Common Amino Acids K

Mass 3108.95

PI 11.06

Basic Residues 9

Acidic Residues 1

Hydrophobic Residues 14

Net Charge +8

Boman Index 8.33

Hydrophobicity 0.076

Aliphatic Index 124.48

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

4

A

0

R

1

N

0

D

0

C

1

E

0

Q

2

G

0

H

3

I

3

L

9

K

1

M

0

F

0

P

1

S

1

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 4 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 9 M: 1 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 3

Length

29

Formula

C142H263N39O35S1

Mass

3108.95

PI

11.06

Net Charge

+8

Boman Index

8.33

Hydrophobicity

0.076

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antimicrobial and Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 1.17 ± 0.23 µM

Detail Source Activity Anticancer

Activity Measurement 1.17

Target

Cancer Type Lung Cancer

Cell Line A-549

Tissue Affected Lung

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 4.93 ± 0.51 µM

Detail Source Activity Anticancer

Activity Measurement 4.93

Target

Cancer Type Colon Cancer

Cell Line HCT-116

Tissue Affected Colon

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 2.46 ± 0.32 µM

Detail Source Activity Anticancer

Activity Measurement 2.46

Target

Cancer Type Liver Cancer

Cell Line HepG-2

Tissue Affected Liver

Assay & Model

Assay MTT assay

Testing Time 48-h

Source & Reference

Database Source CancerPPD 2.0 dbACP

Source CancerPPD2

Year 2019