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Peptide record

TPDB92092

Dermaseptin S4 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB92092
Dermaseptin S4
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with rhodamine B
Sequence
ALWMTLLKKVLKAAAKAALNAVLVGANA-NH2
Physicochemical Analysis
C132H229N35O32S1
RDCEQHIFPSY
A
2850.55
11.00
4
0
20
+4
-1.81
1.032
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
192.95
3
Residue Composition
number
9
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
4
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 4 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C132H229N35O32S1
2850.55
11.00
+4
-1.81
1.032
Amidation
L
Antimicrobial
Linear
Conjugation with rhodamine B
N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3
US 20040132970

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Antimicrobial
Protein derived
Fluorophore (rhodamine)
Cytoplasm
Non-endocytic mechanism
In vitro
CHHHHHHHHHHHHHHHHHHHHSCCCCCC
Additional Detail Fields 1 fields
CHHHHHHHHHHHHHHHHHHHHSCCCCCC