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Peptide record

TPDB92090

PACAP 27 Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB92090
PACAP 27
Antibacterial Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide
Anti-infective peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 Peptipedia B3Pred BBPpredict CPPsite3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Blood-Brain Barrier, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, B3Pred, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2
Physicochemical Analysis
C142H223N39O40S1
NCEPW
AKSY
3148.63
10.06
6
2
13
+3
3.15
-0.415
75.93
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
4470
141.97
8
Residue Composition
number
3
A
2
R
0
N
2
D
0
C
0
E
1
Q
1
G
1
H
1
I
2
L
3
K
1
M
1
F
0
P
3
S
1
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 2 K: 3 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 2
Chemical Descriptors
27
C142H223N39O40S1
3148.63
10.06
+3
3.15
-0.415
Amidation
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC labelled
Levels of internalization of PACAP27 were around 50% of that observed for the TAT (48–60) peptide
In vitro
CCCCCCSSCCSCCSCHHHHHHTGGGCC
Additional Detail Fields 1 fields
CCCCCCSSCCSCCSCHHHHHHTGGGCC