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Peptide record

TPDB92087

NRC-03 NRC-07 Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB92087
NRC-03 NRC-07
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylated
Sequence
GRRKRKWLRRIGKGVKIIGGAALDHL-NH2
Physicochemical Analysis
C132H232N48O29
NCEQMFPSTY
RG
2955.60
12.59
10
1
10
+8
5.52
-0.577
108.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
186.09
0
Residue Composition
number
2
A
5
R
0
N
1
D
0
C
0
E
0
Q
5
G
1
H
3
I
3
L
4
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 1 I: 3 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C132H232N48O29
2955.60
12.59
+8
5.52
-0.577
Amidation
L
Linear
Biotinylated
Antimicrobial
Pleurocidin-family
Evidence Records 23 records
Evidence 1 Activity

Activity

5% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

5% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 3 Activity

Activity

30-35% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 4 Activity

Activity

60% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 5 Activity

Activity

5-10% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 6 Activity

Activity

10% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 7 Activity

Activity

30-35% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 8 Activity

Activity

60% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 9 Activity

Activity

30% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 10 Activity

Activity

50% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 11 Activity

Activity

70% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 12 Activity

Activity

80-85% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 13 Activity

Activity

30% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 14 Activity

Activity

40-50% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 15 Activity

Activity

60-70% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 16 Activity

Activity

80-85% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 17 Activity

Activity

15-20% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 18 Activity

Activity

40-50% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 19 Activity

Activity

80% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 20 Activity

Activity

85-90% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 21 Activity

Activity

~0% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 22 Activity

Activity

70% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 23 Activity

Activity

60-70% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7-TX400
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011