Back to search

Peptide record

TPDB92085

Cf-Melittin Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Neuropeptide Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB92085
Cf-Melittin
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Hemolysis Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 BBPpredict CellPPD-MOD CPPsite3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
N-terminal: Conjugated with 5(6)-Carboxyfluorescein (CF)
Sequence
GIGAVLKVLTTGLPALISWIKRKRQQ
Physicochemical Analysis
C131H228N38O32
NDCEHMFY
L
2847.49
12.43
5
0
12
+5
1.42
0.273
135.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
193.15
5
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
3
I
4
L
3
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 3 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C131H228N38O32
2847.49
12.43
+5
1.42
0.273
Free
L
Cationic
Linear
Conjugated with 5(6)-Carboxyfluorescein (CF)
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Monomac6 Human Monocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
CF dye
Highly membrane disrupting peptide and No difference in cellular uptake slightly between Cf-labelled and non-labelled
In vitro
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC