TPDB

3D PDB MODEL

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TPDB ID TPDB92079

Peptide_Name

V13K

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-KWKSFLKTFKSAKKTVLHTALKAISS-NH2

FASTA

>TPDB92079|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=26
Ac-KWKSFLKTFKSAKKTVLHTALKAISS-NH2

Formula C139H230N36O34

Absent Amino Acids RNDCEQGMPY

Common Amino Acids K

Mass 2949.58

PI 11.29

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +7

Boman Index 2.29

Hydrophobicity -0.215

Aliphatic Index 82.69

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 186.47

Polar Residues 7

number

3

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

3

L

7

K

0

M

2

F

0

P

4

S

3

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 7 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 1

Length

26

Formula

C139H230N36O34

Mass

2949.58

PI

11.29

Net Charge

+7

Boman Index

2.29

Hydrophobicity

-0.215

C_terminal_Modification

Amidation

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Acetylation

Nature

Antimicrobial and Anticancer

Origin

Synthetic

Evidence 1 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 16 ± 0.5 µM

Detail Source Activity Anticancer

Activity Measurement 16

Target

Cancer Type Cervical Cancer

Cell Line HeLa

Tissue Affected Cervix

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2017

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 24.8 ± 0.6 µM

Detail Source Activity Anticancer

Activity Measurement 24.8

Target

Cancer Type Pancreatic Cancer

Cell Line MIA PaCa-2

Tissue Affected Pancreas

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2017

Evidence 3 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 7.6 ± 4.0 µM

Detail Source Activity Anticancer

Activity Measurement 7.6

Target

Cancer Type Pancreatic Cancer

Cell Line HPAC

Tissue Affected Pancreas

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2017

Evidence 4 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 = 12.5 ± 1.2 µM

Detail Source Activity Anticancer

Activity Measurement 12.5

Target

Cancer Type Pancreatic Cancer

Cell Line BxPC-3

Tissue Affected Pancreas

Assay & Model

Assay MTT assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2017