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Peptide record

TPDB92078

LAH4-L1 Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB92078
LAH4-L1
Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia i2APP CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antiparasitic, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, i2APP, and other sources, with an available 3D structural model.
Chemical: Self-assembled polypeptide nanoparticles (PNLS)
Sequence
KKALLAHALHLLALLALHLAHALKKA
Physicochemical Analysis
C132H228N38O27
RNDCEQGIMFPSTWYV
L
2779.50
11.00
8
0
18
+4
0.84
0.923
180.77
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C132H228N38O27
2779.50
11.00
+4
0.84
0.923
Free
Self-assembled polypeptide nanoparticles (PNLS)
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7/Gfp And MCF-7/Adr Cells

Assay & Model

Female BALB/c nude mice( 4–5 weeks old)
Female BALB/c nude mice( 4–5 weeks old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Cy5 labeled siRNA (siMDR1)
Cytoplasm
Mean fluorescence intensities of Cy5 and the percentage of the Cy5-positive cells were significantly higher in PNLS than in the control and naked siRNA groups
Macropinocytosis and clathrin mediated endocytosis
In vitro and in vivo
CCCCC
Additional Detail Fields 1 fields
CCCCC