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Peptide record

TPDB92075

NRC-07 Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB92075
NRC-07
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylated
Sequence
RWGKWFKKATHVGKHVGKAALTAYL-NH2
Physicochemical Analysis
C136H209N39O29
NDCEQIMPS
K
2854.40
11.14
8
0
12
+6
0.56
-0.404
70.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
437.57
3
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
2
H
0
I
2
L
5
K
0
M
1
F
0
P
0
S
2
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 2 I: 0 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 2 W: 2 Y: 1 V: 2
Chemical Descriptors
25
C136H209N39O29
2854.40
11.14
+6
0.56
-0.404
Amidation
L
Linear
Biotinylated
Antimicrobial
Pleurocidin-family
Evidence Records 21 records
Evidence 1 Activity

Activity

5% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

20-30% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 3 Activity

Activity

40-50% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 4 Activity

Activity

~0% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 5 Activity

Activity

10% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 6 Activity

Activity

20% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 7 Activity

Activity

40-50% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
T-47D
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 8 Activity

Activity

~0% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 9 Activity

Activity

20% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 10 Activity

Activity

70-80% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 11 Activity

Activity

80-85% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
SKBR-3
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 12 Activity

Activity

10% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 13 Activity

Activity

50% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 14 Activity

Activity

80% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 15 Activity

Activity

80-90% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MDA-MB-468
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 16 Activity

Activity

30-40% cytotoxic at 5 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 17 Activity

Activity

60-70% cytotoxic at 10 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 18 Activity

Activity

80-90% cytotoxic at 25 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 19 Activity

Activity

85-90% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
4T1
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 20 Activity

Activity

70% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 21 Activity

Activity

60-70% cytotoxic at 50 µM
Anticancer

Target

Breast Cancer
MCF-7-TX400
Breast

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011