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Peptide record

TPDB92068

LEDE Antibacterial Antifungal Cell-penetrating Peptides Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB92068
LEDE
Antibacterial Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia AFP-GFuse CPPsite3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Chemical: Nanoparticle N-terminal: Azide-Modified
Sequence
IGKEFKRIVERIKRFLRELVRPLR
Physicochemical Analysis
C140H243N45O31
ANDCQHMSTWY
R
3052.75
12.12
9
3
10
+6
9.62
-0.513
121.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
3
E
0
Q
1
G
0
H
3
I
3
L
3
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 3 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 3 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C140H243N45O31
3052.75
12.12
+6
9.62
-0.513
Free
Nanoparticle
L
Linear
Azide-Modified
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc 2.4, D1 Spleen-Derived Cell Line , RAW 264.7,Hek 293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Cy5-mRNA (Luc andEGFP) polyplexes (PPx)
The PPx-LEDE formulations both exhibited a weak EGFP expression (<12%),
In vitro
CCHHHHHHHTTSCHHHHTTTTTTSCC
Additional Detail Fields 1 fields
CCHHHHHHHTTSCHHHHTTTTTTSCC