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Peptide record

TPDB92065

LyeTx-I-b Antibacterial Anticancer Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB92065
LyeTx-I-b
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-IWLTALKFLGKNLGKLAKQQLAKL-NH2
Physicochemical Analysis
C129H219N33O29
RDCEHMPSYV
L
2696.36
11.12
5
0
13
+5
-1.03
0.288
142.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
203.98
4
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
1
I
7
L
5
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 1 L: 7 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C129H219N33O29
2696.36
11.12
+5
-1.03
0.288
Amidation
L
Linear
Acetylation
Antimicrobial
Synthetic
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
IC50 = 29.20 ± 7.96 µM
Anticancer
29.20

Target

Brain Tumor
U-87-MG
Brain

Assay & Model

MTT/Resazurin dye assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 20.94 ± 5.18 µM
Anticancer
20.94

Target

Brain Tumor
U-373-MG
Brain

Assay & Model

MTT/Resazurin dye assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019
Evidence 3 Activity

Activity

IC50
IC50 = 93.80 ± 2.17 µM
Anticancer
93.80

Target

Brain Tumor
SH-SY5Y
Brain

Assay & Model

MTT/Resazurin dye assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2019