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Peptide record

TPDB92062

DP-2 Antibacterial Anticancer Antifungal Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB92062
DP-2
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 Antifungipept CAFPdb dbAMP
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
GRKKRRQRRRGALWKSLLKNVGKA-NH2
Physicochemical Analysis
C124H224N50O28
DCEHIMFPTY
R
2863.46
13.11
11
0
7
+11
7.17
-1.550
69.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
192.08
3
Residue Composition
number
2
A
6
R
1
N
0
D
0
C
0
E
1
Q
3
G
0
H
0
I
3
L
5
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 3 K: 5 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
24
C124H224N50O28
2863.46
13.11
+11
7.17
-1.550
Amidation
L
Linear
Free
Antimicrobial and Anticancer
Synthetic
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 3.21 µM
Anticancer
3.21 µM

Target

Lung Cancer
H-157
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 6.75 µM
Anticancer
6.75 µM

Target

Prostate Cancer
PC-3
Prostate

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2018